Highly Efficient Microwave-Assisted Synthesis of 2-Arylimidazo[1,2-a]Pyridine-3-Carbaldehydes in PEG-400

Abstract

We have designed a simple and efficient method for the synthesis of 2-Arylimidazo[1,2-a]pyridine-3-carbaldehyde from imidazo[1,2-a]pyridines with a mixture of DMF and POCl₃ in presence of PEG-400 as a green reaction medium under microwave irradiation at 400 watt, and 90 ⁰C. The main advantages of this protocol compared to other previously developed methods, were its mild reaction condition, high yield percentage, short reaction time, clean reaction profile, and avoidance of toxic catalysts, hazardous organic solvents, and waste production.

Keywords:

• Imidazo[1,2-a]pyridine-3-carbaldehyde
• vilsmeier-haack reagent
• PEG-400
• microwave irradiation

Acknowledgement

The authors sincerely thank Dr. Rafiq Zakaria College for Women’s principal for providing us with the facilities needed to carry out this research.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Author contributions

All of the authors made contributions to the writing of the manuscript, and they all approved of its final version.