Synthesis of Highly Functionalized Imidazopyridine: A Simple One-Pot Three-Component Synthesis of 6-Hydroxy-5 -(3-Phenylimidazo[1,2-a]Pyridin-2-yl)-2-Thioxo-2, 3-Dihydropyrimidin-4(1H)-Ones

Abstract

In this research, synthesis of different imidazopyridine derivatives was performed using aryl glyoxals, thiobarbituric acid, and 2-aminopyridine in the presence of acetic acid in ethanol at 80 °C. Different aryl glyoxals can be used in this method. Finally, the desired products were separated by simple filtration in excellent yields. The salient features of this protocol are a simple operation, mild reaction conditions, simple work up, easy product isolation, and preparation of potentially bioactive compounds.

Graphical Abstract

Keywords:

• Imidazopyridine
• aryl glyoxals
• thiobarbituric acid
• 2-aminopyridine
• one-pot three-component reaction

Acknowledgments

The authors are thankful to the Office of Graduate Studies of the Vali-e-Asr University of Rafsanjan for partial support of this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Vali-e-Asr University of Rafsanjan.