Sodium Oxalate Mediate Synthesis and α-Amalyase Inhibition Assay of 5-Substituted-3-Phenyl-2-Thioxoimidazolidin-4-Ones

Abstract

A newer synthetic methodology of 5-Substituted-3-Phenyl-2-Thioxoimidazolidin-4-Ones has been reported using various amino acids, phenylisothiocyanate, and sodium oxalate in water, the reaction was monitored by chromatographic technique (TLC). Ten compounds were prepared, recrystallized, and characterized by sophisticated analytical methods such as ¹H and ¹³C, NMR, IR, and Mass spectrometry. All the derivatives were screened for α amylase inhibition activity at different concentration level; the final result shows moderate to the good activity which is comparable with the std drug molecule.

Keywords:

• Thioxoimidazolidin-4-Ones
• α-amylase
• S-amino acids

Acknowledgment

All colleagues and contributors are thanked by the authors for their continuous assistance during this study. The Principal of Deogiri College, Aurangabad and Head of the Chemistry Department as well as the Principals and staff of dept. of chemistry of BP Arts, SMA Science, and KKC Commerce College in Chalisgaon are also thanked by GPS.

Disclosure statement

No potential conflict of interest was reported by the author(s).