One-Pot Multi-Component Synthesis of Polysubstituted Pyridines Using DBU-SiO₂ as a Robust Recyclable Catalyst

Abstract

We report an efficient novel route for the synthesis of polysubstituted pyridine derivatives with DBU-SiO₂ catalyzed one-pot four-component reaction. This protocol offers a mild condition that which affords a series of new polysubstituted pyridine derivatives with good yields. A plausible mechanism for this process is proposed.

Keywords:

• Multi-component reaction
• polysubstituted pyridine
• DBU-SiO₂
• heterogeneous catalyst

Acknowledgements

The authors would like to thank Dr. Reddy’s Laboratory, Hyderabad for providing facilities to carry out this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).