Green Synthesis and Biological Study of New Imidazothiazines Using New MCRs: A Combined Experimental and Theoretical Investigation

Abstract

For the performing this research multicomponent reaction of isatin, electron-deficient acetylenic compounds, α-haloketones, ammonium acetate, isothiocyanates and methyl aziridine in aqueous at room temperature was investigated for the production of novel derivatives of azepinothiazine in excellent yields. The synthesized azepinothiazines have OH, NH₂ and NH functional groups that have acidic hydrogen and show high antioxidant activity. These synthesized compounds also displayed antimicrobial activity by using the disk diffusion procedure and two Gram-positive and Gram-negative bacteria. Also, to better understanding reaction mechanism density functional theory-based quantum chemical methods have been applied. The employed process for the production of azepinothiazine has some benefits such as short time of reactions, excellent efficiency of the product, easy separation of products.

GRAPHICAL ABSTRACT

HIGHLIGHTS

• Green chemistry is the use of a set of principles to reduce or eliminate the use or generation of unsafe materials in the design, fabrication and applications of chemical products. Among solvents, water is a green solvents and very suitable for performing organic reaction.

• The present procedure avoids the use of toxic solvent.

• MCRs open diverse avenues to create novel concatenations in one pot fashion leading to diverse biologically potent heterocyclic scaffolds.

Keywords:

• Azepinothiazines
• multi component reaction
• alkyl bromide
• isatins
• gram-positive and gram-negative bacteria

Acknowledgments

The authors gratefully acknowledge the support of Islamic Azad University of Zahedan.

Disclosure statement

No potential conflict of interest was reported by the author(s).