Advanced search
Publication Cover
Numerical Heat Transfer, Part A: Applications
An International Journal of Computation and Methodology
Volume 63, 2013 - Issue 7
Submit an article Journal homepage
193
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Numerical Simulation of a New Probe for the Alternate Cooling and Heating of a Subcutaneous Mouse Tumor Model

Zhanghao Cai School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Mingyang Song School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Aili Zhang School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Jianqi Sun School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
&
Lisa Xuemin Xu School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. ChinaCorrespondence[email protected] [email protected]
Pages 534-548 | Received 06 Jan 2012, Accepted 01 Oct 2012, Published online: 30 Jan 2013
 
Sample our Engineering & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

A new probe for the alternate cooling and heating of a subcutaneous tumor was designed based on numerical simulations in this study. In conjunction with a thermal system built in our lab, it facilitates liquid nitrogen cooling and radiofrequency (RF) heating within one probe. Simulations were performed to study the effects of the probe length, probe inner tube diameter, and liquid nitrogen flow pressure on the probe cooling capacity. Three probes were fabricated with optimized parameters. Experimental measurements were made in gelatin to validate the simulated results and to demonstrate the probe efficiency.

Acknowledgments

This work was supported by the National Natural Science Foundation of China (NSFC11005074, NSFC51076095), the Doctoral Fund of Ministry of Education of China (20100073120004), Shanghai Science and Technology Commission of Shanghai Municipality (11DZ2211000), and the National Basic Research Program of China (973 Program, 2010CB834300).

Notes

*Probes A–D are simulated; probes 1–3 are fabricated.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Cryo-thermal therapy inducing MI macrophage polarization created CXCL10 and IL-6-rich pro-inflammatory environment for CD4+ T cell-mediated anti-tumor immunity.
Source: Taylor & Francis Group

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.