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Numerical Heat Transfer, Part A: Applications
An International Journal of Computation and Methodology
Volume 63, 2013 - Issue 7
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Original Articles

Numerical Simulation of a New Probe for the Alternate Cooling and Heating of a Subcutaneous Mouse Tumor Model

Zhanghao Cai School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Mingyang Song School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Aili Zhang School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
,
Jianqi Sun School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
&
Lisa Xuemin Xu School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. ChinaCorrespondence[email protected] [email protected]
Pages 534-548 | Received 06 Jan 2012, Accepted 01 Oct 2012, Published online: 30 Jan 2013
 
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Abstract

A new probe for the alternate cooling and heating of a subcutaneous tumor was designed based on numerical simulations in this study. In conjunction with a thermal system built in our lab, it facilitates liquid nitrogen cooling and radiofrequency (RF) heating within one probe. Simulations were performed to study the effects of the probe length, probe inner tube diameter, and liquid nitrogen flow pressure on the probe cooling capacity. Three probes were fabricated with optimized parameters. Experimental measurements were made in gelatin to validate the simulated results and to demonstrate the probe efficiency.

Acknowledgments

This work was supported by the National Natural Science Foundation of China (NSFC11005074, NSFC51076095), the Doctoral Fund of Ministry of Education of China (20100073120004), Shanghai Science and Technology Commission of Shanghai Municipality (11DZ2211000), and the National Basic Research Program of China (973 Program, 2010CB834300).

Notes

*Probes A–D are simulated; probes 1–3 are fabricated.

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