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Abstract
The majority of quinolones of clinical use belong to the subset of fluoroquinolones, which have a fluoro group attached the central ring system, typically at the 6-position. Fluoroquinolones are widely used in human and veterinary medicine. In recent times there has been significant development in the field of fluoroquinolones and many new analogues have been synthesized. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies. In this review article, various spectrophotometric methods used for determination of fluoroquinolones have been covered. The methods include visible spectrophotometry, which is based on formation of ion-pair or charge transfer complexes, UV spectrophotometry and derivative spectrophotometry. The application of these methods for the determination of fluoroquinolones in pharmaceutical and real samples has also been discussed.