Linezolid—A Review of Analytical Methods in Pharmaceuticals and Biological Matrices

Abstract

Bacterial resistance to antibiotics is a growing phenomenon in the world. Considering the relevance of antimicrobials for population and the reduction in the registration of new antimicrobials by regulatory agencies, proper quality control is required to minimize the spread of bacterial resistance and ensure the effectiveness of a treatment, as well as safety for the patient. The recent addition to the antimicrobial world is the oxazolidinone classes of antibiotics, especially useful to treat infections caused by Gram-positive bacteria. Eperezolid and linezolid (LIN) are the two members of the oxazolidinone class of antibiotics. LIN was the first oxazolidinone approved by the Food and Drug Administration. The present review focuses on the analytical methods for the assessment of LIN in pharmaceuticals and biological matrices. The critical validation parameters like the linearity, limit of detection, limit of quantification are discussed for the individual method. Also the critical quality attributes like the sensitivity and the sample preparation techniques for bioanalytical methods are also discussed. Furthermore, some future trends that can be incorporated in the determination of similar drugs are also suggested.

Keywords:

• Bioanalytical methods
• chromatographic methods
• Linezolid
• review
• spectrophotometry

Acknowledgments

The authors are thankful to Vice Chancellor, SRM University and management of SRM College of Pharmacy, SRM University, Kattankulathur for providing various reprographic sources for carrying out this work.

Conflict of interest

The authors declare that there are no conflicts of interest.