A Critical Review on Advancement in Analytical Strategies for the Quantification of Clinically Relevant Biological Transporters

Abstract

Success of a drug discovery program is highly dependent on rapid scientific advancement and periodic inclusion of sensitive and specific analytical techniques. Biological membrane transporters can significantly alter the bioavailability of a molecule in its actual site of action. Expression of transporter proteins responsible for drug transport is extremely low in the biological system. Therefore, proper scientific planning in selection of their quantitative analytical technique is essential. This article discusses critical advancement in the analytical strategies for quantification of clinically relevant biological transporters for the drugs. Article cross-talked key planning and execution strategies concerning analytical quantification of the transporters during drug discovery programs.

Keywords:

• Analytical techniques
• biological transporters
• drug discovery
• execution strategies
• quantitation

Acknowledgments

We are thankful to NIPER-A and the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, New Delhi, India for providing the necessary facilities and supports for compiling this review.

Competing interests

The authors have no competing interests to declare.