A Critical Review on Organic Small Fluorescent Probes for Monitoring Carbon Monoxide in Biology

Abstract

Endogenous carbon monoxide (CO) is an important intracellular gas messenger that is intimately involved in many physiological and pathological processes. The abnormal concentration of CO in living organisms can cause many diseases. Therefore, it is of great significance to monitor CO in biological samples. Fluorescent probe technology provides an effective and convenient method for CO monitoring, with the advantages of high selectivity and sensitivity, fast response time and in situ fluorescence imaging in biological tissues, which is favored by the majority of researchers. In this paper, the research progress of CO fluorescent probes since 2018 is reviewed, and the design, detection mechanism and biological application of the related fluorescent probes are summarized. And the relationship between the structure and performance of the probes is discussed. Furthermore, the development trend and application prospect of CO fluorescent probes are prospected.

Keywords:

• Carbon monoxide
• fluorescent probe
• detection mechanism
• review
• research progress

Additional information

Funding

This work was supported by Guangxi Science and Technology Base and Special Fund for Talents (AD19110056), National Natural Science Foundation of China (32060521) and Natural Science Foundation of Guangxi (2020GXNSFDA297023).