Enantioselective Sensors and Biosensors in the Analysis of Chiral Drugs

Abstract

The opportunity to use electrochemical sensors in enantioselective analysis is discussed. Chiral selectors such as crown ethers, cyclodextrins, and enzymes had been used for both chromatographic enantioseparation methods and enantioselective electrochemical sensors and biosensors. New possibilities of membranes construction, like molecular imprinting-based enantioselectivity sensors are also discussed. The advantages of use enantioselective sensors and biosensors over separation methods (HPLC, MEKC, CZE) are presented. The reliability of chiral drugs enantioselective assay is improved by using enantioselective sensors and biosensors.

Keywords:

• enantioselective analysis
• chiral drugs
• electrochemical sensors
• electrochemical biosensors.