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Abstract
It is essential that the novel biomarkers discovered by means of advanced detection tools based on metabonomics could be used for long-term monitoring in food safety. By summarizing the common biomarkers discovery flowsheet based on metabonomics, this review evaluates the possible application of metabonomics in new biomarker discovery, especially in relation to food safety issues. Metabonomics have the advantages of decreasing detection limits and constant monitoring. Although metabonomics is still in the developmental stage, we believe that, based on its properties, such as noninvasiveness, sensitivity, and persistence, together with rigorous experimental designs, new and novel technologies, as well as increasingly accurate chemometrics and a relational database, metabonomics can demonstrate extensive application in food safety in the postgenome period.
ACKNOWLEDGEMENTS
This work is financially supported by the National Natural Science Foundation of China (21071066, 20835006, 91027038, 21101079, 21175034), the Key Programs from MOST (2012BAC01B07, 2012BAD29B05, 2012AA06A303, 2012BAD29B04, 2011BAK10B07, 2011BAK10B05, 2011- BAK10B01, 2010AA06Z302, 2010DFB3047, 2009BAK- 61B04, 2011ZX08012-001, 2010GB2C100167), the grants from Natural Science Foundation of Jiangsu Province, MOF and MOE (BE2011626, BK2010001, BK2010141, 201110060, 201110016, 201110061,311002).