Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious bacterial pathogen that induces high mortality and morbidity. Due to the emergence of multiple resistance, antibiotic treatments are rapidly becoming ineffective for the related infections. Natural products, especially those derived from plants, have been proven to be effective agents with unique antibacterial properties through different mechanisms. This review interprets the resistance mechanisms of MRSA with the aim to conquer public health threat. Further, recent researches about plant antimicrobials that showed remarkable antibacterial activity against MRSA are recorded, including the crude plant extracts and purified plant-derived bioactive compounds. Novel anti-MRSA modalities of plant antimicrobials such as alteration in efflux pump, inhibition of pyruvate kinase, and disturbance of quorum sensing in MRSA are also summarized which may be promising alternatives to antibacterial drug development in future.

Keywords:

• MRSA
• plant antimicrobials
• efflux pump
• pyruvate kinase
• quorum sensing

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (grant 31772079) and the Special Fund for Agroscientific Research in the Public Interest (201403071-5).