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Abstract
Cardiovascular diseases (CVDs) have been ranked as the leading cause of death in the world, whose global incidence is increasing year by year. Citrus, one of the most popular fruits in the world, is rich in flavonoids. Citrus flavonoids attract special attention due to a variety of biological activities, especially in the prevention and treatment of CVDs. The research progress of citrus flavonoids on CVDs have been constantly updated, but relatively fragmented, which needed to be systematically summarized. Hence, the recent research about citrus flavonoids and CVDs were reviewed, including the types and in vivo processes of citrus flavonoids, epidemiology study and mechanism on prevention and treatment of CVDs by citrus flavonoids. This review would provide a theoretical basis for the citrus flavonoids research and a new idea in the citrus industry development and application.
Author’s contribution
Yudi Deng collected the references and wrote the majority of the manuscript. Yali Tu and Shenghui Lao was responsible for the drawing of the figures. Mengting Wu, Hantong Yin and Linqing Wang revised and improved the manuscript. Professor Wenzhen Liao reviewed and approved the final version of the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).