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Abstract
Mycotoxins are metabolites produced by fungi. The widespread contamination of food and feed by mycotoxins is a global food safety problem and a serious threat to people’s health. Most food-borne mycotoxins have strong hepatotoxicity. However, no effective methods have been found to prevent or treat Mycotoxin- Induced Liver Injury (MILI) in clinical and animal husbandry. In this paper, the molecular mechanisms and potential anti-MILI medicines of six food-borne MILI are reviewed, and their targets are predicted by network toxicology, which provides a theoretical basis for further study of the toxicity mechanism of MILI and the development of effective strategies to manage MILI-related health problems in the future and accelerate the development of food safety.
Author’s contributions
Haonan Ruan: Writing - original draft, Data curation, Software, Validation; Qian Lu: Writing - review & editing, Data curation, Software; Jiashuo Wu: Data curation, Visualization; Jiaan Qin: Supervision, Conceptualization; Ming Sui: Software; Xinqi Sun: Data curation; Yue Shi: Supervision, Writing - review & editing; Jiaoyang Luo: Supervision, Conceptualization, Writing - review & editing; Meihua Yang: Supervision, Funding acquisition, Writing - review & editing.
Disclosure statement
The authors have declared that there is no conflict of interest.