The potential role of Piper guineense (black pepper) in managing geriatric brain aging: a review

Abstract

Brain aging is one of the unavoidable aspects of geriatric life. As one ages, changes such as the shrinking of certain parts (particularly the frontal cortex, which is vital to learning and other complex mental activities) of the brain may occur. Consequently, communications between neurons are less effective, and blood flow to the brain could also decrease. Efforts made at the biological level for repair become inadequate, leading to the accumulation of β-amyloid peptide in the brain faster than its probable degradation mechanism, resulting in cognitive malfunction. Subsequent clinical usage of drugs in battling related brain-aging ailments has been associated with several undesirable side effects. However, recent research has investigated the potential use of natural compounds from food in combating such occurrences. This review provides information about the use of Piper guineense (black pepper) as a possible agent in managing brain aging because of its implications for practical brain function. P. guineense contains an alkaloid (piperine) reported to be an antioxidant, anti-depressant, and central nervous system stimulant. This alkaloid and other related compounds are neuroprotective agents that reduce lipid oxidation and inhibit tangles in the brain tissues.

Keywords:

• Brain aging
• Alzheimer’s disease
• depression prevention
• Piper
• black pepper

Acknowledgements

Postdoctoral Research Fellowship granted to Dr. B.M. Fasogbon from the University of Johannesburg (UJ) Global Excellence and Stature (GES) Grant is acknowledged.

Disclosure statement

No potential competing interest.

Additional information

Funding

The Research Did Not Receive Any Specific Grant From Funding Agencies In The Public, Commercial, Or Not-For-Profit Sectors.