Anthocyanins’ effects on diabetes mellitus and islet transplantation

Abstract

The incidence of diabetes mellitus is dramatically increasing every year, causing a huge global burden. Moreover, existing anti-diabetic drugs inevitably bring adverse reactions, and the application of islet transplantation is often limited by the damage caused by oxidative stress after transplantation. Thus, new approaches are needed to combat the growing burden of diabetes mellitus. Anthocyanins are of great nutritional interest and have been documented that have beneficial effects on chronic diseases, including diabetes mellitus. Here, we describe the health effects of anthocyanins on diabetes mellitus and islet transplantation. Epidemiological studies demonstrated that moderate intake of anthocyanins leading to a reduction in risk of diabetes mellitus. Numerous experiments both animal and clinical studies also showed positive effects of anthocyanins on prevention and treatment of diabetes and diabetic complications. These effects of anthocyanins may be related to mechanisms of improving glucose and lipid metabolism and insulin resistance, antioxidant, and anti-inflammatory activities. In addition, damage and function of pancreatic islets after transplantation are also improved by anthocyanins. These findings suggest that daily intake of anthocyanins may not only improve nutritional metabolism in healthy individuals to prevent from diabetes, but also as a supplementary treatment of diabetes mellitus and islet transplantation. Thus, more evidence is needed to better understand the potential health benefits of anthocyanins.

Keywords:

• Anthocyanins
• diabetes mellitus
• islet transplantation
• pre-diabetes

Disclosure statement

No potential conflict of interest was reported by the authors. Figure 3 were created by Figdraw (www.figdraw.com).

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China: No. 81570698 (Dr. Bo Zhang); the key project of Natural Science Foundation of Zhejiang Province (LZ20H160002); key research and development project of Zhejiang province (2021C03048).