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Review Article

Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis

ORCID Icon, ORCID Icon & ORCID Icon
Pages 685-700 | Received 06 Mar 2018, Accepted 24 Jun 2018, Published online: 14 Oct 2018
 

Abstract

Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial pathogenesis gained importance over recent years. SRs regulate the recruitment of immune cells and control both host inflammatory response and bacterial load. In turn, pathogens have evolved different strategies to overcome immune response, avoid recognition by SRs and exploit them to favor infection. Here, we discuss the most relevant findings regarding the interplay between SRs and pathogens, discussing how these multifunctional proteins recognize a panoply of ligands and act as bacterial phagocytic receptors.

Acknowledgements

The authors thank R. Appelberg, for PhD co-supervision of R.P.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work received funding from Norte-01–0145-FEDER-000012 – Structured program on bioengineered therapies for infectious diseases and tissue regeneration, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (FEDER). R.P received an FCT Doctoral Fellowship [SFRH/BD/89542/2012] through FCT/MEC co-funded by QREN and POPH (Programa Operacional Potencial Humano). SS was supported by FCT Investigator program (COMPETE, POPH, and FCT).

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