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Abstract
This issue presents the detailed review paper (DRP) on thyroid hormone disruption assays that was prepared for the Organization for Economic Cooperation and Development (OECD) and that exists as an OECD monograph. However, this document is now available here in one issue of Critical Reviews in Toxicology as a series of published articles. The original document has been modified in several ways. First, an overview (now article 2) was added to discuss how new data and new directions for thyroid research will play an important role in shaping thyroid assays as they evolve. Second, each of the original chapters of the thyroid DRP have been separated into individual papers. The appendices of the original DRP were removed and will be merged and published separately.
| Abbreviation & Definition | ||
| AVT | = | Arginine vasotocin |
| BTEB | = | Basic transcription element-binding protein |
| CBP | = | Cortisol-binding protein |
| CRF | = | Corticotropin-releasing factor |
| CTHBP | = | Cytoplasm TH binding proteins |
| D1 | = | Type I deiodinase |
| D2 | = | Type II deiodinase |
| D3 | = | Type III deiodinase |
| EDSP | = | Endocrine Disruptor Screening Program |
| EPA | = | Environmental Protection Agency |
| FSH | = | Follicle-stimulating hormone |
| GHRH | = | Growth hormone releasing hormone |
| GnRF | = | Gonadotropin-releasing factor |
| IRD | = | Inner-ring deiodinases |
| LH | = | Luteinizing hormone |
| OECD | = | Organization for Economic Cooperation and Development |
| ORD | = | Outer-ring deiodinases |
| PVN | = | Paraventricular nucleus |
| RPA | = | Ribonuclease protection assay |
| RT-PCR | = | Reverse-transription polymerase chain reaction |
| SS | = | Somatostatin |
| T3 | = | Triiodothyronine |
| T4 | = | Thyroxin |
| TBG | = | Thyroxin-binding globulin |
| Tg | = | Thyroglobulin |
| TH | = | Thyroid hormone |
| TRH | = | Thyrotropin-releasing hormone |
| TSH | = | Thyroid-stimulating hormone (thyrotropin) |
| TTR | = | Transthyretin |
| VMG | = | Validation Management Group |
| Abbreviation & Definition | ||
| AVT | = | Arginine vasotocin |
| BTEB | = | Basic transcription element-binding protein |
| CBP | = | Cortisol-binding protein |
| CRF | = | Corticotropin-releasing factor |
| CTHBP | = | Cytoplasm TH binding proteins |
| D1 | = | Type I deiodinase |
| D2 | = | Type II deiodinase |
| D3 | = | Type III deiodinase |
| EDSP | = | Endocrine Disruptor Screening Program |
| EPA | = | Environmental Protection Agency |
| FSH | = | Follicle-stimulating hormone |
| GHRH | = | Growth hormone releasing hormone |
| GnRF | = | Gonadotropin-releasing factor |
| IRD | = | Inner-ring deiodinases |
| LH | = | Luteinizing hormone |
| OECD | = | Organization for Economic Cooperation and Development |
| ORD | = | Outer-ring deiodinases |
| PVN | = | Paraventricular nucleus |
| RPA | = | Ribonuclease protection assay |
| RT-PCR | = | Reverse-transription polymerase chain reaction |
| SS | = | Somatostatin |
| T3 | = | Triiodothyronine |
| T4 | = | Thyroxin |
| TBG | = | Thyroxin-binding globulin |
| Tg | = | Thyroglobulin |
| TH | = | Thyroid hormone |
| TRH | = | Thyrotropin-releasing hormone |
| TSH | = | Thyroid-stimulating hormone (thyrotropin) |
| TTR | = | Transthyretin |
| VMG | = | Validation Management Group |