Response to the letter to the editor regarding the article “Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts” by Garvey et al. (2023)

"Response to the letter to the editor regarding the article “Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts” by Garvey et al. (2023)." Critical Reviews in Toxicology, 53(7), pp. 438–439

Declaration of interest

All authors of Garvey et al. (2023) had complete control over this response to Post (2023) and agree to this response. No authors received funding for preparing this response to Post (2023). The sponsor of the original manuscript had no input or review of this response.

Notes

1 Notably, the Draft for Public Comment U.S. Environmental Protection Agency’s (USEPA) revised technical support documents for PFOA and PFOS maximum contaminant level goals, released in March 2023, still considered the immune endpoint for the point of departure derivation for both compounds, however, this endpoint was no longer used by the agency as the ultimate critical effect for PFOS and was used only in combination with developmental and cardiovascular effects for PFOA (see https://www.epa.gov/system/files/documents/2023-03/MAIN_Proposed%20MCLG%20for%20PFOA%20in%20Drinking%20Water_3.9.23_For%20Proposal.pdf and https://www.epa.gov/system/files/documents/2023-03/MAIN_Proposed%20MCLG%20for%20PFOS%20in%20Drinking%20Water_3.9.23_For%20Proposal_0.pdf).