https://orcid.org/0000-0003-2343-746X
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ABSTRACT
In this study, leaf essential oil effects on glutamate toxicity model formed in cortex neurons and LN405 cell cultures were investigated. Antidiabetic activity was evaluated by α-amylase and α-glucosidase inhibitions. MIC was used for antimicrobial activity. Seven groups were examined with MTT. Glutamate 10-5 mM in cortex showed 62% viability whereas oil viability did not increase in a dose-dependent manner and the highest viability rate was observed. There are four types of glandular trichomes in leaf anatomy of walnut. The oil exhibited half as much α-glucosidase inhibitory activity with an IC50 value of 8105 μg/mL, compared to positive control acarbose (IC50 = 4762 μg/mL). MIC of oil was determined to be 625 μg/mL against E. coli, C. albicans, and C. parapsilosis, whereas S. aureus exhibited a MIC of 1250 μg/mL. Major compounds of oil were found as β-pinene (17.6%), α-pinene (11.3%), β-eudesmol (8.6%), and caryophyllene oxide (6.2%).
Acknowledgments
Enes TEKMAN would like to thank the scholarship along with their postgraduate program provided by the Turkish Scientific and Technical Research Council (TUBITAK).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/10412905.2023.2234372