Determination of radiosensitivity from chest X-ray on human breast cancer cell line MDA-MB-231 in terms of cell morphology and cell proliferation

Abstract

Chest X-rays are used to assess diagnostic conditions for patients with breast cancer. The aim of this research was to study the radiation dose from chest X-ray on the response of breast cancer cells. In this research, the proliferation and cell numbers of the MDA-MB-231 cell line were studied at 1, 24, 48, 72 and 96 h after 0.42–0.82 mGy of chest X-ray irradiation. The results showed that the cell morphology of breast cancer cells did not change after irradiation. In contrast, it was found that the radiation dose from chest X-ray inhibited cell growth and the cell viability of MDA-MB-231. It can be seen that the changes at the cellular level occur within cancer cells from low-dose radiation.

KEYWORDS:

• Radiation
• breast cancer cell line
• MDA-MB-231
• low-dose X-ray
• chest X-ray

Acknowledgements

The authors thank Mr. Nuttapong Danthanavat from the Faculty of Radiological Technology, Rangsit University, Patumthani, Thailand for their assistance.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This project was financially supported by scholarships from the Research Institute of Rangsit University

Notes on contributors

Gunjanaporn Tochaikul

Gunjanaporn Tochaikul is a lecturer in Faculty of Radiological Technology, Rangsit University, Patumthani, Thailand.

Manus Mongkolsuk

Manus Mongkolsuk is a lecturer in Faculty of Radiological Technology, Rangsit University, Patumthani, Thailand.

Krai Daowtak

Krai Daowtak is a lecturer in Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.

Chalermchai Pilapong

Chalermchai Pilapong is a lecturer in Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Nutthapong Moonkum

Nutthapong Moonkum is a lecturer in Faculty of Radiological Technology, Rangsit University, Patumthani, Thailand.