Complete cDNA Coding Sequence of the HLA-DRB1*1405 Allele

Hitoshi Kohsaka Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

Kimio Nasu Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

Sho Matsushita Department of Allergy and Immunology, Saitama Medical School, Saitama, 350-0495, Japan

Nobuyuki Miyasaka Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

Abstract

Cloning report of complete coding region of HLA-DRB1 &#72 1405 has never appeared in the literature. We have isolated and sequenced it from a B cell line with a DRB1 &#72 1405/1502 genotype. The sequence information of this gene and previously published DRB1 genes for the other DR serotypes facilitated us to find that the cytoplasmic domain sequences of DRB1 genes fall into three groups. It is known that antigen presenting cells are differentially activated when products of different MHC class II genes are triggered. Functional analyses would discern if these allelic differences in the cytoplasmic domain are of functional significance.

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Complete cDNA Coding Sequence of the HLA-DRB1*1405 Allele

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Complete cDNA Coding Sequence of the HLA-DRB1*1405 Allele

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