SYNTHESIS OF 3-(2-MERCAPTO-4-THIAZOLYL)-2H-1-BENZOPYRAN-2-ONE AND ITS DERIVATIVES

Abstract

Treatment of 3-(2-bromoacetyl)coumarins with ammonium dithiocarbamate provides 3-2-mercapto-4-thiazolyl)-2H-1-benzopyran-2-one (11) but not 4-hydroxy-4-(3-coumaririnyl) thiazolidine-2-thione (I). II undergoes smooth condensation with alkyl, aralkyl, phenacyl and acid halides to give corresponding thioethers and thioesters (III) respectively. The structures of the newly synthesized compounds were established on the basis of spectral data (IR, PMR and MS).

Key Words:

• Mercaptothiazole
• mercaptothiazolyl coumarin and ammonium dithiocarbamate