THE NOVEL SYNTHESES OF α-TRIFLUOROMETHYLATED KETONES FROM β-BROMOENOL PHOSPHATES

Abstract

A series of 1-aryl-3,3,3-trifluro-1-propanones have been synthesized from the reaction of FO₂SCF₂CO₂Me with β-bromoenol phosphates in the presence of Cul in moderate yield. The reaction mechanism was discussion, the electron-withdrawing substituent at the β-position of the enol phosphates promoted the catalytic cleavage of the O-P bond in enol phosphates by fluoride ion.

Key Words:

• Trifluoromethylated ketones
• β-bromoenol phosphates