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Original Articles

A FACILE ONE-POT SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF AZIRIDINES AND THIAZINES FROM 1,3-DIARYLPROP-2-ENONES

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Pages 15-27 | Received 27 Feb 2000, Accepted 18 Aug 2000, Published online: 27 Oct 2006
 

Abstract

The title compounds 1a,b as examples for acyclic alkenones were utilized for the synthesis of some heterocycles namely, thiazines 2a,b and 3a-d, pyrimidines 4a,b. aziridines 7a,b. The unexpected tribromides 8a,b, obtained from bromination of 1a,b, were readily used to afford the pyrazoles 9a,b and isoxazoles 10 a,b. Biological screening of some selective synthesised compounds was determined in vitro using Gram-negative and Gram-positive bacterial strains.

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