Synthesis of Arsenical Adduct: Synthesis and Transformation of Dimercapto Compound to Arsenical Adduct

Abstract

Reaction of isothiocyanates with thioamide in presence of pyridine afforded 1,3-dimercapto substrates in good yield. Adipoin reacts with phenylarsine oxide and triphenylarsine to give the bicyclic 1,3,2-dioxarsole derivatives. A variety of 1,3,2-arsadithiolane derivatives were obtained by reaction of 1,3-dimercapto substrate with arsenic trioxide, phenylarsine oxide, triphenylarsine triphenylarsine oxide in ethanol or better in chloroform.

Keywords:

• 1,3,2-arsadithiolane Derivatives
• 1,3-dithiol Compounds
• 1,3,2-dioxarsole Derivatives
• Arsenic Compounds
• Isothiocyanates
• Thioamide