Synthesis and Study of the Thermal Epimerization of r -2-Ethoxy- cis -4- cis -5-Dimethyl-1,3,2-λ 3 -Dioxaphospholane Using 31 P NMR

Abstract

The exclusive synthesis of r -2-ethoxy- cis -4- cis -5-dimethyl-1,3,2- u 3 -dioxaphospholane ( cis - 1 ) is reported. The kinetic measurements of the epimerization of cis - 1 to trans - 1 were performed by 31 P NMR from 50 to 80;C in toluene. The energy of activation (E a ) of the epimerization process was calculated from Arrhenius plot. The thermodynamic parameters of the transition state led us to conclude that the activation barrier of the inversion at phosphorus is driven by the enthalpy and by a large and negative entropy of activation.

Keywords:

• 1,3,2-λ³-dioxaphospholanes
• Inversion At Phosphorus
• Kinetic Studies
• Synthesis
• Thermodynamic Parameters Of The Transition State