Synthesis, Characteristic Spectral Studies and in Vitro Antimicrobial Activity of Organosilicon(IV) Complexes of N-(2-Hydroxynaphthalidene)-Amino Acid Schiff Bases

Abstract

Fifteen new organosilicon(IV) complexes formulated as R 3 Si[2-HOC 10 H 6 CH=NCH(X)COO] and Me 2 Si[2-OC 10 H 6 CH=NCH(X)COO] (where X = H[H 2 L 1 ], --CH 2 CH(CH 3 ) 2 [H 2 L 2 ], --CH 2 CH 2 -SCH 3 [H 2 L 3 ], --CH 3 [H 2 L 4 ] and --CH(CH 3 ) 2 [H 2 L 5 ] were prepared and characterized by 1 H and 13 C NMR, IR, electronic spectral studies, and elemental analysis. All of the complexes are nonelectrolytes. The spectral studies suggested a distroted trigonal-bipyramidal geometry around the silicon atom. Antimicrobial activity screening for all of the complexes was carried out against various bacteria [ Escherichia coli, Aeromonas formicans, Pseudomonas putida-2252, and Staphylococcus aureus-740 ] and fungi [ Aureobasidium pullulans-1991, Penicillium chrysogenum-1348, Verticillium dahliae-2063, and Aspergillus niger ORS-4 ]. The complexes showed good activity.

Keywords:

• Amino Acids
• Antimicrobial Activity
• Multinuclear Nmr
• Organosilicon(IV)
• Schiff Bases