A Convenient Two-Step One-Pot Synthesis of Alkylthiophosphoramidates Derivatives

Zhi-Wei Miao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China

Hua Fu The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China

Bo Han The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China

Yi Chen The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China

Yu-Fen Zhao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, 100084, China

Abstract

N-thiophosphonylamino groups have been greatly overlooked as potentially potent, transition-state analogues, or tetrahedral--intermediate inhibitors of metalloproteases. Alkylthiophosphoramidates derivatives were synthesized y reaction of O-isopropyl phosphorodichloridothioate with an amino acid este followed by hydrolysis in 2M NH 4 OH. The reaction was monitored by 31 P NMR spectroscopy.

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A Convenient Two-Step One-Pot Synthesis of Alkylthiophosphoramidates Derivatives

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A Convenient Two-Step One-Pot Synthesis of Alkylthiophosphoramidates Derivatives

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