Synthesis of N 1 -Substituted, N 3 -[ P -(3-Ethoxy-Carbonyl-4,5-Dihydronaphtho[1,2- c ]Pyrazol-2-YL)Benzenesulfonyl]Urea and Thiourea Derivatives. Class of Cyclooxygenase-2 Inhibitors

Hassan M. Faidallah Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

Salem A. Basaif Chemistry Department, Faculty of Science, University of King Abdulaziz, Jaddah, Saudi Arabia

Essam M. Sharshira Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

Abd El-Kader A-Ba-Oum Chemistry Department, Faculty of Science, University of King Abdulaziz, Jaddah, Saudi Arabia

Abstract

Several urea and thiourea derivatives ( 2a-f ) were prepared by the reaction of dihydronaphthopyrazolylbenzenesulfonamide ( 1 ) with the corresponding isocyanates and isothiocyanates, respectively. The benzenesulfonylthioureas ( 2d , e ) were cyclized with ethyl bromoacetate, ethyl g -bromopropionate and f -bromoacetophenones to give the corresponding 4-oxothiazolidine ( 3a , b ), 4-oxo-5,6-dihydrothiazine ( 4a , b ) and thiazoline derivatives ( 5a-d ) respectively.

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Synthesis of N 1 -Substituted, N 3 -[ P -(3-Ethoxy-Carbonyl-4,5-Dihydronaphtho[1,2- c ]Pyrazol-2-YL)Benzenesulfonyl]Urea and Thiourea Derivatives. Class of Cyclooxygenase-2 Inhibitors

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Synthesis of N 1 -Substituted, N 3 -[ P -(3-Ethoxy-Carbonyl-4,5-Dihydronaphtho[1,2- c ]Pyrazol-2-YL)Benzenesulfonyl]Urea and Thiourea Derivatives. Class of Cyclooxygenase-2 Inhibitors

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