Synthesis of Phenyl or 4-Nitrophenyl Methyl β-Ketophosphonate Esters

Abstract

Seven new aryl methyl g -ketophosphonate esters were synthesized. The hydrolytic rates of the compounds under physiological conditions were studied. Most of the compounds are effective inhibitors of acetylcholinesterase. The enzyme recovers on the 10-50 h time scale from its adducts with two of the inhibitors.

Keywords:

• Aryl Alkylphosphonate Esters
• Ketoalkyl Aryl Phosphonate Esters
• Reversible Inhibitors
• Serine Hydrolase Inhibitors