Conformationally Rigid Hosts Containing Phosphonic Units

Abstract

We present here a new class of cleft-like receptor molecules containing two or four phosphonates anions, tailored for multipoint binding of their substrates. Depending on the accessibility of the cleft, these hosts are water soluble and selective for short or long f , y -diammonium compounds. Due to their inherent chirality, we found that only those host-guest combinations which allow a three-point-interaction were effective.

Keywords:

• Chiral Recognition
• Job-plots
• Macrocycles
• Supramolecular Chemistry