Synthesis of Competitive Inhibitors of Phospholipase A 2 (PLA 2 )

Abstract

The synthetic routes for preparation of several phospholipid analogues such as lithium alkyl-3-alkoxy allylvinyl-sn-glycerol 5 and 6 and lithium trans-2-amidomethyl phosphate 7 and lithium cholesterol ester phosphate 8 containing ether, amide, and phosphate ester moieties are described.

Keywords:

• Inhibitor
• Phospholipase A 2 (PLA 2 )
• Phospholipid