New Synthetic Route and Characterisation of Phosphorus and Arsenic Heterocyclic Compounds

Abstract

Herein we report synthetic routes for the preparation of 2-chloro-1,3,2-dioxarsenane 1 , O,O'-bis(5,5-dimethyl-1,3,2-dioxarsenane)-2,2-dimethyl-1,3-propanediol 3 , 2-chloro-1,3,2-dioxaphosphorinane 4 , and 2-fluoro-1,3,2-dioxaphosphorinane 5 . The new synthetic routes described here have the advantage to be simple, very clean and to lead to the desired compounds in very good yields. Compound 2-fluoro-1,3,2-dioxarsenane 2 also was prepared in good yield and is described here for the first time. Compounds 1-5 were fully characterized on the basis of NMR spectroscopic studies. Semi-empirical structural studies have been carried out and the results show that 1 and 2 exist as a mixture of two conformers, whereas only one conformer for 4 and 5 have been found. Variable temperature 1 H NMR studies reveal a fluxional behaviour for 1 and a mechanism for the inter-conversion between its two conformers is proposed.

Keywords:

• Arsenic
• Conformation
• Nmr Studies
• Phosphorus
• Semi-empirical Calculations