Efficient Synthesis of Highly Functionalized, S -Alkyl 1-Alkyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carbothioates

Abstract

5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts with alkyl isocyanides in the presence of this to produce S -alkyl 1-alkyl-4,4-dimethyl-2,5-dioxo-pyridine-3-carbothioates in good yield.

Keywords:

• Alkyl Isocyanides
• Alkylidene Meldrum's Acid
• Pyrrolidine
• S -alkyl Carbothioate
• S -alkyl Thioester
• Thiols