Michael Addition of Activated Nitriles to 4[(+)-Camphor-10′-Sulfonylamino]acetophenone and Some of its Chalcones

Abstract

4-[(+)-Camphor-10'-sulfonylamino]acetophenone ( 2 ) and some of its chalcones 3 were easily prepared in quantitative yields starting from (+)-camphor-10-sulfonyl chloride. Several new 2-oxo-, 2-thio-, as well as 2-amino-pyridines carrying the camphor sulfonylamino group as a substituent were synthesized easily in one step by Michael addition of several activated nitriles to compounds 2 and 3 . The synthesis of some fused pyridines also was investigated.

Keywords:

• α,β-unsaturated Ketones
• Activated Nitriles
• Camphor-10-sulfonyl Chloride
• Deazapyrimidines
• Pyridinethiones
• Pyridones