Synthesis and Antimicrobial Activity of Some New Cyanopyridines, Isoxazoles, Pyrazoles, and Pyrimidines Bearing Sulfonamide Moiety

Abstract

Reaction of p-aminoacetophenone 1 with p -substituted benzenesulfonyl chloride 2a , b in pyridine afforded p-acetyl derivatives 3a , b , which was then condensed with araldehydes to yield the corresponding chalcones 4a-f . On condensation of latter chalcones with malononitrile afford cyanopyridines 5a-f , the reaction of chalcones 4a-f with hyroxylamine hydrochloride furnished isoxazoles 6a-f , while condensation of chalcones with hyrazine hydrate afforded pyrazoline derivatives 7 , 8 . Urea or thiourea was reacted with chalcone 4b to yield pyrimidine derivatives 9 , 10 . The reaction of sulphonylchlorides 2a , b with P -aminobenzophenone yield p-[(benzensulphonyl)amido]benzophenone 11a , b , which was then condensed with hydrazine hydrate to give the corresponding hydazone derivatives 12a , b .

Keywords:

• Antimicrobial Activity
• Cyanopyridines
• Isoxazoles
• Pyrazoles And Pyrimidines
• Sulfonamide
• Synthesis