PHASE TRANSFER CATALYZED SYNTHESIS OF THIOSEMICARBAZIDE AND bis-THIOSEMICARBAZIDE DERIVATIVES OF 2-ETHOXYBENZOIC ACID

Abstract

Reaction of aryloxyacetic acid hydrazide or arenedioxydiacetic acid hydrazide with 2-ethoxybenzoy chloride and ammonium thiocyanate under the condition of solid–liquid phase transfer catalysis using polyethylene glycol-400 (PEG-400) as the catalyst yielded the corresponding thiosemicarbazide or bisthiosemicarbazide derivatives of 2-ethoxybenzoic acid in good-to-excellent yield.

Keywords:

• Bis-thiosemicarbazide
• phase transfer catalysis
• thiosemicarbazide

This work was supported by Natural Science Foundation (No. 20371040) of China, the Foundation (031-A21-004) of Gansu province, and the Foundation (No. 02-18) of Northwest Normal University, which are gratefully acknowledged.