DIPHOSPHINE COMPOUNDS: PART I. NOVEL BIOLOGICALLY ACTIVE 1,1′bis-AND/OR 1,2-cis-(DIPHENYLPHOSPHINO-)ETHENE AND THEIR COMPLEXES [M(CO)_n{Ph₂P(CH_n)_nPPh₂}] & [Cu(Cl)₂{Ph₂P(CH_n)_nPPh₂}], (M = W, Mo, Crn = 1,2….n)

Abstract

Interaction of [Ph₂PC(═CH₂)PPh₂] (A)^1–3 and/or [Ph₂P (CH═CH) PPh₂](B) ligands in different molar ratio with hexacarbonyl metals M(CO)₆ gives [M(CO) _n Ph₂PC(═CH₂)PPh₂] and/or [M(CO) _n Ph₂P (CH═CH)PPh₂ where M═ Cr, Mo or W, n = 2 and/or 4]. The carbon diphosphine complexes of type (A) which form four heteromemebered rings and/or type (B) form five heteromembered rings which reacts (addition reaction) with some different amines (methyl amine, dimethyl amine), phenyl hydrazine and/or some of amino acids (glycine, alanine, aspartic acid, serene). The structures of A and/or B complexes and their amino derivatives have been characterized by using elemental analysis, IR spectra, ¹HNMR,¹H-³¹P-NMR, and mass spectra. Ligands and their complexes were screened in vitro to investigate the biological activities (antibacterial and antifungi). Interestingly, complexes are having strong and remarkable activities increases than the free ligands.

Keywords:

• Antimicrobial screening
• carbon diphenyl-phosphine derivatives
• organometallic
• transitions metal complexes

Notes

a = CH;

b = CH₂;

o, m, p = ortho, meta, para.

^a DSM = Deutsche Semmlungvos Microorgamifman (German Collection of microorganisms).

^b AUCC = Assiut University Culture Collection.

^c (−ve) = Compound not active biological.

^d ATCC = America Culture Collection.

^e CBS = Holland culture collection.