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Original Articles

SYNTHESIS OF SOME 2-[(BENZAZOLE-2-YL)THIO]-DIPHENYLMETHYLACETAMIDE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY

, , , , &
Pages 2183-2188 | Received 01 Mar 2004, Accepted 01 Mar 2004, Published online: 16 Aug 2010
 

Abstract

Some 2-[(benzazole-2-yl)thio]diphenylmethylacetamide[3pc] derivatives were synthesized by reacting 2-chloroacethylaminodiphenylmethane with benzazole-2-thions. The structure elucidation of the compounds was performed by IR, 1 H NMR, and MS-FAB spectral data.

Antimicrobial activity of the compounds was examined. Some of the compounds have shown similar antifungal activities against C. albicans when compared with ketoconazole. It was also observed that some of these compounds have moderate antimicrobial activity when compared with chloramphenicole.

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