SYNTHESIS OF 4,9-DIMETHYL-8- (6-ARYL-2-THIOXO-1,2,3,6-TETRAHYDRO PYRIMIDIN-4-YL)-FURO[2,3-H]CHROMEN-2-ONES AS ANTIMICROBIAL AGENTS UNDER MICROWAVE IRRADIATION

Abstract

Acrolyl furochromen-2-ones (3a–i) obtained in good yields on microwave irradiation of furochromen-2-one (1) with various simple and substituted aromatic aldehydes (2a–i). 3a–g on cyclo dehydration with thiourea in domestic microwave oven furnished tetrahydro thiaxopyrimidine furochromen-2-ones 4a–i in high yields. The structures of the newly synthesized compounds were established on the basis of analytical and spectral data, IR, and ¹H NMR.

Keywords:

• Aryl acrolyl furochromen-2-ones
• furochromen-2-one
• tetrahydro thiaxopyrimidine furo chromen-2-ones

Acknowledgments

The authors are thankful to UGC for the financial assistance, and greatly thankful to Dr. Kirity Roy, Principal Research Scientist, Nicholas Piramal India Limited for screening anti-microbial activity of the compounds. The authors are also thankful to Director IICT Hyderabad for providing NMR spectra.