SYNTHESIS AND FUNGICIDAL ACTIVITIES OF DERIVATIVES OF 2-ALKYLTHIO-3-AMINO-4H-IMIDAZOL-4-ONE

Abstract

2-Alkylthio-3-phenylamino-5-arylmethylene-4H-imidazol-4-ones 5 were synthesized by S-alkylation of 3-phenylamino-2-thioxo-4-imidazolidinones 4, which were obtained via cyclization of isothiocyanates 2 with phenylhydrazine in presence of solid potassium carbonate. Compound 5 exhibited fungicidal activity.

Keywords:

• 4H-Imidazol-4-one
• aza-Wittig reaction
• fungicidal activities
• synthesis

Acknowledgments

We gratefully acknowledge financial support of this work by the National Key Project for Basic Research (2003CB114400, 2003CB114406) and the National Natural Science Foundation of China (Project No. 20102001).

Notes

*Isolated yields of 4 or 5 based on iminophosphosphorane 1 or imidazolidinone 4, respectively