SYNTHESIS OF SOME NEW PROPANOL DERIVATIVES ANALOGOUS TO FLUCONAZOLE

Abstract

A series of 2-(2,4-difluorophenyl)-1-(1H-1,2,4 triazol-1-yl-methyl)-3-(substituted heterocycl)-propan-2-ol, which are analogous to fluconazole, were synthesized via the reaction of 2-(2,4-difluorophenyl)-2-[1-(1,2,4-triazolmethide)]oxiran with various heterocyclic systems.

Keywords:

• Fluconazole
• propanol
• triazine
• triazole