Synthesis of Some N¹-(3-Hydroxy-2-pyridyl)benzamides

Benzoxazoles are of special interest because of having various types of biological properties such as antihistaminic, antihelmintic antifungal and antibacterial activities. ¹ , ² , ³ , ⁴ , ⁵ , ⁶ , ⁷ , ⁸ , ⁹ , ¹⁰ Benzamide derivatives, as the possible metabolites of benzoxazoles, show various types of biological activities. ¹¹ , ¹² Some N-(2-hydroxyphenyl)- benzamides, which showed significant activity compared to phenylacetamides and furamides,11 have been synthesized by treating 2-aminophenol with carboxylic acid chlorides under weak basic solution. ¹¹ , ¹² However, synthesis and especially biological activity of N-(3-hydroxy-2-pyridyl)benzamides were not studied well. Owing to the versatility of benzamides we have extended the reaction of 2-amino-3-pyridinol with different carboxylic acid chlorides in order to preparation of some new benzamide derivatives containing a hydroxypyridyl ring.

keywords:

• 2-Amino-3-pyridinol
• 3-hydroxy-2-pyridyl
• benzamide