Convenient Synthesis of Some 4′-Methtylthio–Containing Aryl and Arylfuryl Pyrazolines and Their Antimicrobial Activity Studies

The condensation of 4-acetylthioanisole with different aryl and aryfuryl aldehydes under aldol conditions affords α, β-unsaturated ketones (propenones), which undergo a facile and clean cyclization with hydrazines to give pyrazolines (4–6) in quantitative yields. The structures of newly synthesized compounds have been confirmed on the basis of spectral studies. All newly synthesized compounds were tested for their antibacterial and antifungal activity.

Keywords:

• 4-Acetylthioanisole
• aryfuryl aldehydes
• antimcrobial
• propenones
• pyrazolines

Acknowledgments

The authors are grateful to the Head, R.S.I.C., Punjab University, Chandigarh, SAIF, IISc Bangalore and Head, SAIF, I.I.T., Madras for providing elemental analysis, IR, ¹H NMR, and mass spectral data. The authors are also grateful to the Chairman, Department of Biochemistry, Gulbarga University for providing antibacterial and antifungal activity data for the compounds. The authors are greatful to Strides Research and Speciality Chemicals Division, Mangalore for their cooperation and encouragement.