The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents

Abstract

The synthesis of novel thioureido derivatives 3, 8, and 10; biscompounds 7, 9, and 11; and tetracyclic compounds 5, 6, and 16 utilizing 5-isothiocyanato-3-methyl-thiophene-2,4-dicarboxylic acid diethyl ester 2 are reported. The structures of these compounds were confirmed by microanalyses and IR, ¹H NMR, and mass spectroscopy. Preliminary biological studies of some of the synthesized compounds showed promising radioprotective and anticancer activities.

Keywords:

• Anticancer agents
• new thiophene and thieno[2,3-d]pyrimidine derivatives
• radioprotective

Notes

^†Each value represents the mean of six-observations ± SE (7 days after radiation exposure).

*Significance of change between groups.

^†Each value represents the mean of six-observations ± SE (7 days after radiation exposure).

*Significance of change between groups and control.

^†Each value represents the mean of six-observations ± SE.

*Significant of change between groups and control.