A One-Pot Synthesis of Thiophenes and Their Annulated Derivatives With Potential Pharmaceutical Interest

Abstract

The reaction of 2-cyanomethylene benzo[d]imidazole (1) with carbon disulphide in basic DMF solution gave the di-potassium disulphide salt (3). The reaction of the latter with the α -halocarbonyl compounds 4 and 13 afforded the thiophene derivatives 5 and 14, respectively. The latter products were used to synthesize annulated products with potential pharmaceutical interest.

Keywords:

• Benzo[d]imidazole
• carbon disulphide
• thieno[3,2-b]pyridine
• thiophene

Acknowledgments

The screening antimicrobial tests were recorded by Professor S. A. Ouf and his research group, Department of Botany, Faculty of Science, Botany Department; his efforts were greatly appreciated.