The Synthesis and Fungicidal Activities of 2,6-Bis[(3-aryl)-s-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl]pyridines

Abstract

In search of better bioactive compounds, a series of novel 2,6-bis[(3-aryl)-s-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl]pyridines 2 were synthesized in high yields by the cyclization of 3-aryl-4-amino-5-mercapto-1, 2, 4-triazoles 1 with 2,6-pyridine dicarboxylic acid. 2 exhibited good fungicidal activities against Cerospora beticola sacc.

Keywords:

• 3-aryl-4-amino-5-mercapto-1,2,4-triazole
• 2,6-bis[(3-aryl)-s-triazolo[3,4-b]-[1,3,4] thiadiazole-6-yl]pyridines
• fungicidal activities
• synthesis

Acknowledgments

We gratefully acknowledge financial support of this work by the Natural Science Foundation of Hubei Province Education Committee of China (Project No. D200660001).

Notes

^a Purified yields of 2a–2p 2,6-pyridine dicarboxylic acid.