Abstract
Dihydropyridines (DHP) having a heterocyclic aryl substituent at position-4 are calcium channel antagonists. In this report a new group of DHP derivatives with different esters at the C 3 and C 5 position (asymmetrical diesters) containing 2,4-dichloro-5-thiazolyl at position-4 were synthesized by a condensation reaction of alkyl, cycloalkyl, and aryl acetoacetate in the presence of ammonium acetate in a new shorter pathway. The structure of all compounds was confirmed by IR, 1 H NMR, and mass spectrometry. The calcium channel antagonist activity of compounds 6a–6f demonstrated that the compound 6a was the most active compound.
Acknowledgments
This research was supported by grants from the research council of Tehran University of Medical Sciences and Iran National Science Foundation (INSF), Tehran, Iran.